STUDENTS:MUHAMMAD SARWAR HOSSAIN

Name of United Graduate School of Agricultural Sciences:Tottori University
Assigned university:Shimane university
Specialized field:Application of Raman Spectroscopy on Biomedical Science and Singular-cell levels
Research Theme:Space- and time-resolved study on the effect of the antifungal drug at the single-cell level by Raman microspectroscopy
Obtained (planned) degree/date:Doctor of Philosophy Ph.D. (Bioresource and Life Sciences) Obtained in March 2022 (scheduled)

Cellular pharmacokinetics and pharmacodynamics are emerging field in pharmacology research and has recently attracted much attention owing to their potential in evaluating drug efficacy. By studying the dynamic profiles of drug uptake, distribution, metabolism, and efflux into the extracellular environment, we can derive detailed information about PK/PD and construct models that can help in drug discovery and development. Such an approach integrates cellular physiology and pharmacology, which needs an effective way to study single cells without involving fractionation methods.  Hence, we plan to utilize confocal Raman microscopy to visualize the dynamics of drug-induced metabolic changes, at the single-cell level. To demonstrate the application of Raman spectroscopy to study single-cell pharmacology.

By this technique, I also apply it in living single-cell levels and various fields like environmental chemistry and this technique is being popular day by day as an alternative technique.